TARGETING CD28, CTLA-4 AND PD-L1 COSTIMULATION DIFFERENTIALLY CONTROLS IMMUNE SYNAPSES AND FUNCTION OF HUMAN REGULATORY AND CONVENTIONAL T-CELLS.

Targeting CD28, CTLA-4 and PD-L1 costimulation differentially controls immune synapses and function of human regulatory and conventional T-cells.

CD28, CTLA-4 and PD-L1, the three identified ligands for CD80/86, are pivotal positive and negative costimulatory molecules that, among other functions, control T cell motility and formation of immune synapse between T cells and antigen-presenting cells (APCs).What remains incompletely understood is how CD28 leads to the activation of effector T ce

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Research Progress of Workplace Violence among General Practitioners at Home and Abroad: Prevalence, Influencing Factors, and Intervention Strategies

General practitioners are medical personnel with high integrated degree, and are the "gatekeepers" of residents' health.Violent incidents affecting health care not only seriously harm the the physical and psychological health of general practitioners, also affect the quality and level of basic medical services, which increases the tu

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Gastrointestinal parasite infestation in the alpine mountain hare (Lepus timidus varronis): Are abiotic environmental factors such as elevation, temperature and precipitation affecting prevalence of parasite species?

Information concerning factors regulating Alpine ethical nutrients mega magnesium powder citrus 450g mountain hare (Lepus timidus varronis) populations such as host-parasite interactions is missing as only a few parasitological surveys exist of this subspecies.Parasites are not only dependent on their host but also on suitable environmental conditi

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Endocranial Morphology of the Primitive Nodosaurid Dinosaur Pawpawsaurus campbelli from the Early Cretaceous of North America.

BackgroundAnkylosaurs are one of the least explored clades of dinosaurs regarding endocranial anatomy, with few available descriptions of braincase anatomy and even less information on brain and inner ear morphologies.The main goal of this study is to provide a detailed description of the braincase and internal structures of the Early Cretaceous no

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